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[36] [37] [38] A long-term study where vitamin B 12 was supplemented across a period of 10 years, led to lower levels of weight gain in overweight or obese individuals (p 20% of elderly individuals showed evidence of marginal vitamin B 12 depletion (serum vitamin B 12 : 148221 pmol/L)

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

Hkon Ihle-Hansen: nothing to disclose

B12 lipotropic injections are a supplement therapy combining vitamin B12 with lipotropic compounds designed to support metabolism, energy production, and fat breakdown

If several of these sound like you, it may be time to explore b12 injections for tiredness and weakness with a trained pharmacist