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(paediatric nephrologist, chair and founder of PCRRT)

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Figure 3 (below) provides an overview of the nature of these unmet needs, as well as strategies and the level of competition to address them (based on current clinical development pipelines)

An additional post-hoc sensitivity analysis was performed by excluding the ITCA 650 trial [9] to investigate both primary and secondary outcomes to validate the robustness of the pooled analysis (Supplementary Appendix D)