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Those who smoked half a pack to 20 packs of cigarettes per year had a 27% higher risk than those who didn't smoke

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There are more than 7,000 chemicals in tobacco smoke, including hundreds that are toxic and about 50 of them that can cause cancer

The most common adverse effects of metformin are gastrointestinal, including diarrhea, nausea, abdominal discomfort, and metallic taste, occurring in up to 30% of patients

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