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Two experts in tobacco and nicotine addiction (JR and KF) and two experts in self-report measure development (TS and SC) reviewed the proposed conceptualization and contributed to the development of the first draft measure, which included nine items that characterized the degree of perceived dependence on three different response scales (intensity, frequency, or duration) adapted to the characteristics of the individual symptoms (see Supplementary Table S2)
Snuff is finely cut or powdered, cured tobacco that can be dry, moist, or packaged/portioned in sachets
They bind strongly to the cholesterol in the cell membranes of predators, and in so doing, they disrupt the structure of those membranes, causing cells to leak or burst open upon contact