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Annals of Internal Medicine, 162 (4), 248257.

doi:10.1007/s00125-013-2841-0

Thus, the synergistic effects of exercise and polyphenol supplementation on brain function are mediated through the modulation of neurotrophic signaling, neurotransmitter balance, inflammatory responses, oxidative stress, mitochondrial function, and kynurenine metabolism

The STZR group displayed a relatively preserved cytoarchitecture with reduced neuronal loss and fewer signs of vacuolization compared to untreated diabetic rats