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Similarly, nanoparticles can potentially be used to deliver therapeutics to the brain in a two-step targeting strategy that exploits the high impermeability of the BBB to selectively retain ligand labels on the surface of brain endothelium [170]

Studies using the GABA analog in Fmr1 knockout mice demonstrated corrections in hyperactivity and modulation of altered sensory-motor gating, measured as increased prepulse inhibition following acute treatment, by enhancing the activity of extrasynaptic GABA receptors, thereby improving anxiety, aggression, and repetitive behavioral abnormalities in FXS mice (71)

Despite the peptide's apparent potency, the short-term nature of these studies has been insufficient for researchers to observe the effects of elevated GH levels, such as enhanced muscle growth or lean mass development

J Endocrinol Invest (2008) 31:98590