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It was initially described by both Adolf Jarisch and Karl Herxheimer at the end of the 19th century 1

In the case of organic compounds, biotransformation steps are often necessary and their nature, mechanism(s), responsible enzymes and related polymorphisms are well characterized and the respective role in determining individual sensitivity to the effects of exposure at different levels is a well-established field of investigation

Glutathione is a natural antioxidant the key to health and youth

The antioxidant activity of 4-hydroxycoumarin derivatives and some sulfured analogs