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Overall, compared with the large and growing amount of pre-clinical and mechanistic evidence highlighting the reward-modulating and thus potentially anti-addictive properties of GLP-1RAs, only a few studies have investigated thus far the potential use of these medications in clinical populations with alcohol- or other substance-use disorders

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Colonic L cells contain twice as much GLP-1 peptide than proximal intestine L cells (Reimann et al., 2008)

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