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GLP-1 receptor agonists and gastrointestinal effects: Medications such as semaglutide commonly cause nausea, vomiting, and abdominal discomfort (per the Wegovy SmPC), which may be difficult to distinguish from, or may worsen, existing endometriosis-related gastrointestinal symptoms such as bloating and bowel pain

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Many people are eager to see results quickly and skip the lower doses, but the microdosing and titration data shows that gradual escalation produces better long-term outcomes