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When to Seek Medical Attention for Back Pain Most back pain associated with weight loss and GLP-1 therapy is mechanical (postural or muscular) and resolves with conservative care

Code availability RNA-seq data have been deposited in GEO and are available under the accession link The data in Fig

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Eligibility Criteria Eligibility criteria for all target trials included a prior diagnosis of type 2 diabetes, a recent medical encounter for type 2 diabetes diagnosis in the past year ( active type 2 diabetes ), prescriptions of antidiabetic medications (semaglutide, tirzepatide, or other antidiabetic medications) between December 2017 and January 2023, and diagnosis with at least 1 condition among the prescription guidelines for semaglutide and tirzepatide (eg, obesity, hypertension, hypercholesterolemia, heart disease, stroke, kidney disease, or an A 1C level 8.5%)