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Apixaban is contraindicated in severe hepatic impairment (Child-Pugh C) and used with caution in moderate impairment (Child-Pugh B)

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Digestion was completed by heating the samples to 90 C for 20 min, followed by dilution into an equal volume of hydrogen peroxide (30% Aristar BDH) and incubation for ~30 min period, allowing for effervescence to stop