Reduced MALAT1 expression links to polycystic ovary syndrome (PCOS)-associated ovarian dysfunction, highlighting its potential as a biomarker and therapeutic target in PCOS
Alternative treatments such as dipeptidyl peptidase-4 inhibitors and sodium glucose cotransporter- 2 inhibitors were insufficient substitutes, highlighting the essential role of continuous GLP-1 receptor agonist therapy in maintaining metabolic health
It also helps mobilize liver fat, which is why retatrutide is being studied for fatty liver disease (NASH)
In CNS samples from MS patients increased X-box binding protein 1 ( XBP1) and increased astrocyte-specific inositol-requiring enzyme-1 (IRE1) activation were detected, confirming their contribution to MS pathology (Wheeler et al., 2019), and Linuron activating signaling via sigma receptor 1, IRE1, and XBP1 amplify proinflammatory response and drive pathogenic activities in astrocytes
Nigerian Annals of Pure and Applied Sci 1:176185 Fathy A, Ibrahim AB, Abd Elkhalik S, Villinger A, Abbas SM (2022) Trivalent Cobalt Complexes with NNS Tridentate Thiosemicarbazones: Preparation, Structural Study and Investigation of Antibacterial Activity and Cytotoxicity against Human Breast Cancer Cells