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In cellular stress induced by MPP+, the knockdown of ATF-4 or CTH resulted in a reduction of GSH levels [43, 44]
Neurodegenerative diseases Astroglial decline in the ageing brain Ageing is the main risk factor for many diseases, including an extended spectrum of neurodegenerative disorders leading to senile dementia
(1997) Structure 5 : 1287-1295 PubMed: 9351803 Search on PubMed DOI: Primary Citation Related Structures: 1AQV, 1AQW, 1AQX PubMed Abstract: Glutathione S-transferases (GSTs) are detoxification enzymes, found in all aerobic organisms, which catalyse the conjugation of glutathione with a wide range of hydrophobic electrophilic substrates, thereby protecting the cell from serious damage caused by electrophilic compounds
Insulin resistance significantly affects public health
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