The characteristics of glutathione are the following: (a) discovered by Hopkins in 1921 [67], (b) synthesized intracellularly by glutamate-cysteine ligase and glutathione synthetase [68], (c) exists in reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance [69], (d) functions in melanogenesis inhibition through tyrosinase suppression and pheomelanin synthesis [70], and (e) oral bioavailability is enhanced through liposomal formulations, S -acetyl derivatives, or co-administration with precursors [71]
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It does so by reducing melanin production through the inhibition of the enzyme tyrosinase, and by converting eumelanin (dark pigment) into pheomelanin (a lighter, reddish-yellow pigment)
No one knows for sure, but evidence supports the theory that the increase in free radicals and the resulting oxidative damage is partially to blame
Zinc and human health: an update
