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In vivo, intrastriatal 3-HK alone produces limited neuronal loss, but co-administration with QA results in synergistic excitotoxic and oxidative injury that is attenuated by NMDAR antagonists and free radical scavengers [156]

From another perspective, our findings serve as reverse evidence that further positively supports the consistent results presented by numerous international studies so far: GLP-1RA treatment can indeed bring cardiovascular benefits and safety to diabetic patients

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