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Williamson et al., 2005

Lancet Diabetes Endocrinol (2022) 10:393406

In this review, we provide a comprehensive description of the diverse roles for GLP-1 across multiple tissues, describe downstream pathways stimulated by acute and chronic exposure, and discuss novel pleiotropic applications of GLP-1 mimetics in the treatment of human disease

Amgens statement added that the long half-life, combined with its dual mechanism of action, means the drug may allow for greater durability or reduce the likelihood of weight regain after treatment stops

These reports can be helpful, but theyre not the same as large studies designed to answer safety questions