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CD8 + cytotoxic T lymphocytes, reactive to TPO and Tg, promote glandular destruction, aided by increased ICAM-1 expression on follicular cells and elevated serum levels of VCAM-1 and TIMP-1

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Additionally, individuals taking medications that may interact with B12, including metformin or proton pump inhibitors, should consult a healthcare provider before starting supplementation

S2A) nanoparticles following a modified protocol [31]

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