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It has been determined that a specific aminopeptidase-like enzyme is responsible for its low molecular stability in vitro, with a half-life of barely 15 minutes

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McGeer EG, McGeer PL

Androgens, including testosterone, play a significant role in influencing the skin's physiology

Other in vitro studies suggest that gliadin itself increases intestinal permeability indirectly by promoting the release of zonulin, a protein that induces TJ disassembly and is present in the submucosa of active coeliac patients at concentrations sixfold greater than healthy controls (Fasano et al