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Furthermore, in a chronic social defeat stress mouse model of depression, inhibiting intestinal T cells with TCR and antibodies could directly prevent stress-induced T-cell accumulation in the meninges and subsequent behavioral deficits [337]

[PubMed ID: 18227430]

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Because brain tissue is rarely obtainable in living autistic cohorts, we leveraged blood-based immune phenotyping as a practical window into immune perturbations relevant to central nervous system (CNS) disease processes