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Hydrophobic BAs, such as chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA), have been shown to impair epithelial barrier function by disrupting the expression and structural integrity of tight junction proteins, including Occludin, ZO-1, and Claudins 151

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Rapid ligand-receptor binding and efficient uptake by target cells are critical for receptor-targeted delivery systems to avoid in vivo clearance

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Lawyers from Eli Lilly made an aggressive early play asking the judge when they could file for summary judgment