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Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

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as the most promising candidate for in vivo studies (81), AZD5248 showed aortic binding in a rat quantitative whole-body autoradiography study, so its development was stopped (193)

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Common issues include nausea, vomiting, diarrhea, and constipation, which are typically mild to moderate and most frequent during dose escalation