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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear

48 Chiu, Y.-W., Chang, J.-M., Hwang, S.-J., Tsai, J.-C

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Fibroblasts were comprised of three distinct clusters, including inflammatory, fibrotic and mesothelial cells, which is consistent with recent studies 30,31