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For C677T, the enzyme activity of heterozygous and homozygous mutant individuals are respectively 67 and 25% of the wild-type ones

266 In a placebo-controlled trial in subjects with major depressive disorder, those taking omega-3 fatty acids in addition to an SSRI had lower anxiety sensitivity and improved sleep and emotional regulation after 12 weeks compared with those taking an SSRI plus placebo

Increased SOD2 activity weakens the accumulation of mitochondrial reactive oxygen species (ROS) in spatially constrained cancer cells, thereby supporting the survival of tumor cells in blood vessels in lung tissue and accelerating tumor metastasis in mice (68)