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Table of Contents The link between metabolism and neurodegeneration How GLP-1 receptor agonists may affect the brain Current clinical evidence in Parkinsons disease Practical implications for clinicians FAQs Understanding the Metabolic Connection in Parkinsons Disease Parkinsons disease has traditionally been viewed as a movement disorder caused by dopamine neuron loss in the substantia nigra

No significant changes in GLP-1 secretion were observed at any time point compared to the untreated controls (Figure 2)

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However, the 28-day reconstitution window complicates this slightly

Furthermore, most of the potential redox modifiers described above were only efficacious in SOD1 G93A mice, and these mice do not develop the TDP-43 pathology present in almost all ALS cases