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It has been described that patients may have up to 10 ED visits per year, with over 5 ED visits before the correct diagnosis (130)

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In HFD-fed Atg7 cKO mice and Parkin KO mouse models, some investigators found that deletion of Atg7 and Parkin inhibited mitophagy increased lipid accumulation, and exacerbated diastolic dysfunction, whereas injection of Tat-Beclin1 (TB1) increased mitophagy and attenuated cardiac dysfunction [174]