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Rehman J, Benet A, Melman A

Such a strategy has been demonstrated in the case of cholangiocarcinoma, where IDH1 mutations resulted in the production of the oncometabolite 2-hydroxyglutarate, leading to epigenetic alterations and changes in the expression of key genes involved in cell differentiation and survival [202]

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These three pathological processes drive the progression of DR from the non-proliferative to the proliferative stage and induce retinal neurodegeneration through cascade amplification and positive feedback regulation

Maintenance of results without needing constant escalation suggests you've found a sustainable concentration