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V., Tuttle, K

These individuals are at an increased risk from environmental factors, including microbes and food components, interacting with the subepithelial immune system and entering systemic circulation to promote chronic inflammation and tissue damage in multiple extraintestinal sites

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Patients groups are then defined by time-dependent development of irAEs, such as before and after the landmark, with clinical outcomes only considered if occurring after the landmark [23]

Several antioxidants have been shown to exhibit antioxidant, anti-inflammatory, and anti-microbial properties in in vitro and in vivo models of air pollution exposure