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Do the work and if the work is good, success will follow

Half of all patients reach DSS 6 (moderate disability, basically unable to walk unaided) within 12-15 years after onset

10.1134/S0362119710040110 41 FryA

Interestingly, DA may also directly inhibit mitochondrial respiration [103] and DA oxidation generates toxic quinones and ROS leading to mitochondrial dysfunction [104]