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However, complete inactivation of monophenolase activity in jr PPO1-wt was achieved only when both activity controller residues were mutated (Asn240Lys/Leu244Arg and Asn240Thr/Leu244Arg)

Once an OCD diagnosis has been made, severity can be graded using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impressions (CGI) scale , or both: The Y-BOCS is a clinician-administered 10-item questionnaire that rates the frequency, severity, and types of symptoms in an OCD patient, and can be used to monitor disease progression or treatment

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10.1111/j.1474-9726.2009.00517.x

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