how to break a stall on tirzepatide Has anyone lowered their dose and later increased it plateau? : r/Zepbound Not losing weight on tirzepatide?

Think of it as less goes in, less comes out. Fewer bowel movements can be normal ( even as few as three per week ), but experiencing hard stool, difficulty passing stool, bloating, abdominal pain, or incomplete evacuation would be considered constipation

Cardiovascular, Mortality, and Renal Outcomes Over a median followup of 4.0 years, threepoint MACE occurred in 801 patients (12.2%) in the tirzepatide group and 862 (13.1%) in the dulaglutide group

(2023, Peptides) is worth reading alongside Willard for a mechanistic comparison of tirzepatide and semaglutide that goes beyond the raw binding numbers to receptor residence times and signaling bias

If the room was hot (above 30 degrees), err on the side of discarding

This does double duty for gallbladder protection