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doi: 10.1038/nm.4102 119 QuintanaFJBassoASIglesiasAHKornTFarezMFBettelliEet al

Enterocytes, particularly blood vessel capillaries, lung epithelium, immune cells, and intestinal enterocytes all have high DPP4 levels (activated myeloid cells, T, B, and natural killer cells)

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Cystinosin deficiency leads to impaired lysosomal clearance and disrupted endolysosomal trafficking, which in turn contributes to defective autophagy and altered proteostasis [144, 146, 147]