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EMBO Journal

This medication should not be prescribed to individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2), because there is an increased risk of developing thyroid C-cell tumors

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Additionally, repeated intramuscular injections can cause localized inflammation, tissue damage, and injection site pain that subcutaneous technique avoids

In those early preclinical studies, which were done before these drugs were ever used in humans, there was concern about whats called C cell tumors, which are very specific and rare types of thyroid cancer, being found in rats