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Mechanism of trypsin-induced endothelium-dependent vasorelaxation in the porcine coronary artery

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FDA Category 2 status AOD-9604 was previously nominated for inclusion under FDA's Category 2 list (substances proposed for compounding under research/evaluation)

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A 2024 phase 2 trial published in Nature Medicine enrolled 98 adults with confirmed obesity and fatty liver, treating them with retatrutide once weekly for 48 weeks