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[PubMed: 10933584] 107
4) notably indicated that, in EG110 cells grown in ethanol medium, aspirin significantly downregulated the expression of genes involved in central energy metabolism, particularly in pathways of acetyl-CoA synthesis and metabolite transport to the mitochondria
This serves as a cautionary note that apparent axonal contacts at low magnification may be deceiving, and that enhanced microscopy may be needed to reveal true contacts
The highly complex and multifactorial nature of AD/ADRD and the high prevalence of mixed pathologieswhich may result from common and pathology-specific mechanismssuggest that targeting a single pathology or mechanism is unlikely to be sufficient for preventing or treating AD/ADRD on a large scale
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