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This facilitates metastasis by enhancing cytoskeletal dynamics and cellular invasiveness, particularly promoting bone metastases-a lethal characteristic of advanced PCa [24,30]

When endothelial dysfunction chokes off this supply, the mitochondria are forced to operate in a hypoxic environment, leading to inefficient energy production and a massive increase in the generation of mitochondrial reactive oxygen species (mtROS)

doi: 10.1007/s10534-006-9062-7 381 WalshD