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A pivotal study (Yano et al., Cell, 2015) showed that the microbiota influence the serotonergic system through an entire constellation of metabolites many produced by spore-forming Clostridia, the same group known for butyrate and broad gut-supportive functions

The respective precursor plasmids and primers are reported in Supplementary Tables 4 and 5

doi: 10.1038/s41589-019-0330-6 57 PatelSJProtchenkoOShakoury-ElizehMBaratzEJadhavSPhilpottCC

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Noticeable changes typically appear after 6-8 weeks of consistent treatment, although some may observe improvement earlier