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32,33 Thus, due to the complexity of the HIF signaling cascade and intricacies of nephron anatomy, substantial uncertainty remains regarding the impact of available treatments on HIF signaling and whether such alterations are beneficial to patients with DKD

Although the efficacy of tretinoin in melasma management has been established, however, a minimum treatment duration of 24 weeks is required to achieve the clinical effectiveness

The secretion of growth factors such as hepatocyte growth factor (HGF) and interleukin-10 (IL-10) by MSCs plays a critical role in modulating the inflammatory response, promoting angiogenesis, and recruiting endogenous progenitor cells to the site of injury

[12] Actuarial Research Corporation